Get Apoptosis, Senescence and Cancer PDF

By David A. Gewirtz, Shawn E. Holt, Steven Grant

ISBN-10: 1617376213

ISBN-13: 9781617376214

This booklet presents perception into verified practices and study into apoptosis and senescence. the amount completely examines novel and rising thoughts and learn within the fields of cellphone loss of life pathways, senescence development arrest, medications and resistance, DNA harm reaction, and different themes that also carry mysteries for researchers. In overall, this quantity offers uncomplicated scientists and clinicians with a deeper and extra entire figuring out of the mobile responses of malignancies that can verify the effectiveness of remedy, either within the preliminary phases of the ailment in addition to in sickness recurrence.

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Extra info for Apoptosis, Senescence and Cancer

Example text

Nature 2002; 417:182–7. 44. Hanayama R, Tanaka M, Miyasaka K, et al. Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science 2004; 304(5674):1147–50. 45. Fadok VA, Bratton DL, Rose DM, Pearson A, Ezekewitz RA, Henson PM. A receptor for phosphatidylserine-specific clearance of apoptotic cells. Nature 2000; 405:85–90. 46. Hoffmann PR, deCathelineau AM, Ogden CA, et al. Phosphatidylserine (PS) induces PS receptormediated macropinocytosis and promotes clearance of apoptotic cells.

182. Chai J, Du C JW, Kyin S, Wang X, Shi Y. Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature 2000; 406(6798):855–62. 183. Liu Z, Sun C, Olejniczak ET, et al. Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain. Nature 2000; 408(6815):1004–8. 184. Deveraux QL, Reed JC. IAP family proteins – suppressors of apoptosis. Genes Dev 1999; 13: 239–52. 185. Deveraux QL, Roy N, Stennicke HR, et al. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases.

257. Michalak EM, Villunger A, Erlacher M, Strasser A. Death squads enlisted by the tumour suppressor p53. Biochem Biophys Res Commun 2005; 331:786–98. 258. Vousden KH, Lu X. Live or let die: the cell’s response to p53. Nat Rev Cancer 2002; 2(8):594–604. 259. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990; 61:759–67. 260. Hollstein M, Sidransky D, Vogelstein B, Harris CC. p53 Mutations in Human Cancers. Science 1991; 253(5015):49–53. 261. Di Cristofano A, Pandolfi PP.

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Apoptosis, Senescence and Cancer by David A. Gewirtz, Shawn E. Holt, Steven Grant


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